Online Gamers Help Crack AIDS Enzyme Folding Puzzle
Online gamers have achieved a feat beyond the realm of Second Life or Dungeons and Dragons: they have deciphered the structure of an enzyme of an AIDS-like virus that had thwarted scientists for a decade. The exploit is published on Sunday in the journal Nature Structural & Molecular Biology, where — exceptionally in scientific publishing — both gamers and researchers are honoured as co-authors. Their target was a monomeric protease enzyme, a cutting agent in the complex molecular tailoring of retroviruses, a family that includes HIV. To the astonishment of the scientists, the gamers produced an accurate model of the enzyme in just three weeks. It appears that Foldit was used to help solve the puzzle.
“We wanted to see if human intuition could succeed where automated methods had failed,” Firas Khatib of the university’s biochemistry lab said in a press release. “The ingenuity of game players is a formidable force that, if properly directed, can be used to solve a wide range of scientific problems.”
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